RT journal article
T1 High First Trimester Levels of TSH as an Independent Risk Factor for Gestational Diabetes Mellitus: A Retrospective Cohort Study
A1 Fernández Alba, Juan Jesús
A1 Castillo Lara, María
A1 Jiménez Heras, José Manuel
A1 Moreno Cortés, Rocío
A1 González Macías, María del Carmen
A1 Vilar Sánchez, Angel
A1 Carral San Laureano, Florentino
A1 Moreno Corral, Luis Javier
A2 Enfermería y Fisioterapia
A2 Materno-Infantil y Radiología
K1 gestational diabetes mellitus
K1 subclinical hypothyroidism
K1 subclinical hyperthyroidism
K1 thyroid stimulating hormone
K1 thyrotropin
K1 thyroid antibodies
AB Although numerous articles have found an association between alterations in thyroid function and the risk of gestational diabetes mellitus (GDM), other studies have failed to demonstrate this association. This may be due to the different cut-off points used to define subclinical hypothyroidism. We aim to clarify the role of thyroid stimulating hormone (TSH) level in GDM within pregnant women with normal free thyroxine (fT4) levels. This retrospective cohort study was performed in 6775 pregnant women. The association between TSH and GDM was assessed by bivariate and multivariate logistic regression. Pregnant women with subclinical hypothyroidism are at significantly greater risk for GDM when compared with euthyroid pregnant women (OR = 1.85; 95% CI = 1.36-2.52). We have also observed that TSH levels increase the risk of GDM within euthyroid pregnant women, since the TSH levels between 2.5 and 4.71 showed a higher risk of GDM than those whose TSH levels are between 0.31 and 2.49 (OR = 1.54; 95% CI = 1.28-1.84). In addition, pregnant women with positive thyroid antibodies have almost 2.5 times the risk of developing GDM (OR = 2.47; 95% CI = 1.57-3.89). Our results support that in pregnant women with normal fT4 levels, higher first trimester TSH level implies a higher risk of GDM.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-07
LK http://hdl.handle.net/10498/27565
UL http://hdl.handle.net/10498/27565
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026