RT journal article
T1 Peptide Tyrosine-Tyrosine Triggers GLP-2-Mediated Intestinal Hypertrophy After Roux-en-Y Gastric Bypass
A1 Pérez Arana, Gonzalo Martín
A1 Díaz Gómez, Alfredo Luis
A1 Camacho Ramírez, Alonso
A1 Ribelles García, Antonio
A1 Almorza Gomar, David
A1 Gracia Romero, Manuel Ángel
A1 Prada Oliveira, José Arturo
A2 Anatomía y Embriología Humana
A2 Estadística e Investigación Operativa
K1 Type 2 diabetes mellitus
K1 Roux-en-Y gastric bypass
K1 Enterohormones
K1 Peptide tyrosine-tyrosine
K1 Glucose transporter
K1 Pancreas
K1 Intestinal tube
K1 RYGB
K1 Incretines
K1 PYY
AB Purpose Intestinal remodeling and adaptation of the alimentary limb after Roux-en-Y gastric bypass (RYGB) play an important role in the pathophysiological events that lead to type 2 diabetes mellitus (T2DM) improvement. Intestinal absorptive loop hypertrophy and growth following surgery have been related to GLP-2 secretion by ileal L-cells. The secretion of peptide tyrosine-tyrosine (PYY) enterohormone after a meal has been proposed as a trigger for ileal secretion of GLP-1. Our aim is to determine the role of PYY as a GLP-2 secretion modulator as an adaptation result in the alimentary limb after RYGB.Method We used a non-obese euglycemic rodent model. Circulating glucose, insulin, PYY, and GLP-2 were measured in the experimental and control groups. We used four groups: fasting control, Sham-operated, RYGB-operated (RYGB), and RYGB-operated and treated with BIIE0246 (RYGB + BII). BIIE0246 is a NPY2 receptor antagonist in L-cells. Intestinal glucose transporters and GLP-1 and PYY gut expression and hypertrophy were analyzed after 12 weeks of surgery.Results RYGB increased PYY3-36 plasma levels in rats with or without BIT treatment. A high-insulin response was observed in the RYGB group but not in the control or RYGB +BII groups. BIIE0246 treatment limited plasma GLP-2 levels. In the alimentary intestinal limb, hypertrophy and SGLT1 and GLUT1 expression appeared to be reduced after RYGB compared to controls.Conclusion The postprandial ileal PYY secretion is enhanced after RYGB. This increase mediates GLP-2 release through its binding to the Y2 receptor on L-cells. This mechanism plays a role in alimentary limb hypertrophy after surgery.
PB SPRINGER
SN 1708-0428
YR 2022
FD 2022-12
LK http://hdl.handle.net/10498/27842
UL http://hdl.handle.net/10498/27842
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026