RT journal article
T1 Epigenetic clocks in relapse after a first episode of schizophrenia
A1 González Segura, Álex
A1 Prohens, Llucia
A1 Mezquida, G.
A1 Amoretti, Silvia
A1 Bioque, Miquel
A1 Ribeiro, M.
A1 Gurriarán-Bas, Xaquin
A1 Rementería, Lide
A1 Berge, Daniel
A1 Rodriguez-Jimenez, R.
A1 Roldán, Alexandra
A1 Pomarol-Clotet, Edit
A1 Ibáñez, Angela
A1 Usall, J.
A1 García Portilla, María Paz
A1 Cuesta, Manuel J.
A1 Parellada, M.
A1 González-Pinto, A.
A1 Berrocoso Domínguez, Esther María
A1 Bernardo, Miquel
A1 Mas, Sergi
A1 2EPS group
A2 Psicología
AB The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p=0.030). Shorter telomere length was associated with cognitive performance (working memory, r=0.31 p=0.015; verbal fluency, r=0.28 p=0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.
PB SPRINGERNATURE
SN 2754-6993
YR 2022
FD 2022-07
LK http://hdl.handle.net/10498/27935
UL http://hdl.handle.net/10498/27935
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026