RT journal article
T1 Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults
A1 Montes de Oca García, Adrian
A1 Corral Pérez, Juan
A1 Velázquez Díaz, Daniel
A1 Pérez-Bey, Alejandro
A1 Rebollo Ramos, María
A1 Marín Galindo, Alberto
A1 Gómez-Gallego, Félix
A1 Calderón Domínguez, María
A1 Casals Vázquez, Cristina
A1 Ponce González, Jesús Gustavo
A2 BiomedicinaBiotecnología y Salud Pública
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 genetic association studies
K1 cardiometabolic risk
K1 metabolism
K1 healthy lifestyle
K1 PPARGC1A
K1 caucasian, obesity
K1 physical exercise
AB This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C > T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 +/- 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C > T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p < 0.001). The recessive model (CC vs. CT/TT) showed similar results but also with differences in basal metabolism (p = 0.045) and total energy expenditure (p = 0.024). A genotype*sex interaction was found in the QUICKI index (p = 0.016), with differences between CC and CT/TT in men (p = 0.049) and between men and women inside the CT/TT group (p = 0.049). Thus, the PPARGC1A gene rs8192678 C > T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C > T polymorphism on the QUICKI index.
PB FRONTIERS MEDIA SA
SN 1664-042X
YR 2022
FD 2022-07
LK http://hdl.handle.net/10498/27984
UL http://hdl.handle.net/10498/27984
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026