RT journal article
T1 Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (S-s)-DS-ONJ
A1 Gómez Jaramillo, María Laura
A1 Cano-Cano, Fátima
A1 Sánchez-Fernández, Elena M.
A1 Ortiz Mellet, Carmen
A1 García-Fernández, José M.
A1 Alcalá, Martin
A1 Álvarez-Gallego, Fabiola
A1 Iturregui, Marta
A1 González Montelongo, María del Carmen
A1 Campos Caro, Antonio
A1 Arroba Espinosa, Ana Isabel
A1 Aguilar Diosdado, Manuel
A2 BiomedicinaBiotecnología y Salud Pública
K1 inflammation
K1 diabetic nephropathy
K1 epithelial mesenchymal transition
K1 autophagy
K1 (Ss)-DS-ONJ
AB Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN)in the early stages of the disease. The authors demonstrate that the glycolipid mimetic (Ss)-DS-ONJis able to abolish inflammation via the induction of autophagy flux and provokes the inhibition ofinflammasome complex in ex vivo and in vitro models, using adult kidney explants from BB rats. Thecontribution of (Ss)-DS-ONJ to reducing inflammatory events is mediated by the inhibition of classicalstress kinase pathways and the blocking of inflammasome complex activation. The (Ss)-DS-ONJtreatment is able to inhibit the epithelial-to-mesenchymal transition (EMT) progression, but onlywhen the IL18 levels are reduced by the treatment. These findings suggest that (Ss)-DS-ONJ could bea novel, and multifactorial treatment for DN.
PB MDPI
SN 1422-0067
YR 2022
FD 2022-08
LK http://hdl.handle.net/10498/27992
UL http://hdl.handle.net/10498/27992
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 14-nov-2026