RT journal article
T1 Trace elements as potential modulators of puberty-induced amelioration of oxidative stress and inflammation in childhood obesity
A1 González-Domínguez, Álvaro
A1 Domínguez Riscart, Jesús
A1 Millan-Martinez, Maria
A1 Mateos Bernal, Rosa María
A1 Lechuga Sancho, Alfonso María
A1 González-Domínguez, Raúl
A2 BiomedicinaBiotecnología y Salud Pública
A2 Materno-Infantil y Radiología
K1 childhood obesity
K1 inflammation
K1 oxidative stress
K1 puberty
K1 trace elements
AB Although puberty is known to influence obesity progression, the molecular mechanisms underlying the role of sexual maturation in obesity-related complications remains largely unexplored. Here, we delve into the impact of puberty on the most relevant pathogenic hallmarks of obesity, namely oxidative stress and inflammation, and their association with trace element blood status. To this end, we studied a well-characterized observational cohort comprising prepubertal (N = 46) and pubertal (N = 48) children with obesity. From all participants, plasma and erythrocyte samples were collected and subjected to metallomics analysis and determination of classical biomarkers of oxidative stress and inflammation. Besides the expected raise of sexual hormones, pubertal children displayed better inflammatory and oxidative control, as reflected by lower levels of C-reactive protein and oxidative damage markers, as well as improved antioxidant defense. This was in turn accompanied by a healthier multielemental profile, with increased levels of essential elements involved in the antioxidant system and metabolic control (metalloproteins containing zinc, molybdenum, selenium, and manganese) and decreased content of potentially deleterious species (total copper, labile free iron). Therefore, our findings suggest that children with obesity have an exacerbated inflammatory and oxidative damage at early ages, which could be ameliorated during pubertal development by the action of trace element-mediated buffering mechanisms.
PB Wiley
SN 1872-8081
YR 2023
FD 2023-04-03
LK http://hdl.handle.net/10498/28626
UL http://hdl.handle.net/10498/28626
LA eng
NO This research was funded by the Spanish Government through Instituto de Salud Carlos III (PI22/01899, PI18/01316). Alvaro Gonzalez-Dominguez is supported by an intramural grant from the Biomedical Research and Innovation Institute of Cadiz (LII19/16IN-CO24), and Raul Gonzalez-Dominguez is recipient of a "Miguel Servet" fellowship funded by Instituto de Salud Carlos III (CP21/00120).
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026