RT journal article T1 Could Acidified Environments Intensify Illicit Drug Effects on the Reproduction of Marine Mussels? A1 da Silva Souza, Lorena A1 Bonnail, Estefanía A1 Alves Luzzi, Julia A1 César, Augusto A1 Valls Casillas, Tomás Ángel del A1 Seabra Pereira, Camilo Dias A2 Química Física K1 CO2 enrichment K1 crack cocaine K1 early life stages K1 climate change effects K1 Perna perna AB The increasing oceanic uptake is a direct response to the increasing atmospheric burden of CO2. Oceans are experiencing both physical and biogeochemical changes. This increase in CO2 hosts in oceans promotes changes in pH and seawater chemistry that can modify the speciation of compounds, largely due to dependent element speciation on physicochemical parameters (salinity, pH, and redox potential). So, ocean acidification can trigger enhanced toxicity of illicit drugs to non-target marine organisms due to the combined effects of crack cocaine and low pH (from 8.3 to 7.0 pH values) on the reproduction of the marine mussel Perna perna. Fertilization rate and embryo-larval development were used as endpoints to assess the effects of crack-cocaine concentrations (6.25, 12.5, 25, 50, and 100 mg L-1) and its association with pH values variation (8.3, 8.0, 7.5, and 7.0). The IC50 was calculated from the results of an embryo-larval assay in different methods of acidification (CO2 and HCl), which evidenced that HCl treatment was more toxic than CO2 treatment for the same drug concentrations. Results showed that the gametes of P. perna react to acidification when exposed to crack-cocaine concentration and pH reductions. PB MDPI SN 2076-3417 YR 2022 FD 2022-11 LK http://hdl.handle.net/10498/28807 UL http://hdl.handle.net/10498/28807 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 11-nov-2026