RT journal article
T1 Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species
A1 Guzzo, Francesca
A1 García Durán, Alexandra
A1 Sanna, Cinzia
A1 Marasco, Rosangela
A1 Molfetta, Nicola
A1 Buommino, Elisabetta
A1 Fiorentino, Antonio
A1 D’Abrosca, Brigida
A2 Química Orgánica
K1 Myrtus communis
K1 gallomyrtucommulone
K1 structural elucidation
K1 NMR analysis
K1 antimicrobial assay
K1 Staphylococcus epidermidis
K1 Staphylococcus aureus MRSA
AB Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against Staphylococcus species, bioactive fractions of Myrtus communis L., growing in the Sardinia island (Italy) have been investigated. Their phytochemical analysis led us to isolate and characterize four alkylphloroglucinol glycosides (1-4), three of them gallomyrtucommulones G-H (1,2), and myrtucommulonoside (4) isolated and characterized for the first time. The structures of the new and known compounds, endopreroxide G3 (5), myricetin-3-O-glycosides (6,7) were determined based on the spectroscopic evidence including 1D-/2D-NMR and HR-MS spectrometry. Enriched fractions as well as pure compounds were tested for their antimicrobial activity by broth micro-dilution assay against Staphylococcus epidermidis and S. aureus. Results reported herein demonstrated that gallomyrtucommulone G (1) showed a selective antimicrobial activity against both S. aureus strains (ATCC 29213 and 43300) until 16 mu g/mL while gallomyrtucommulone D (3) showed the best growth inhibition value at 64 mu g/mL.
PB MDPI
SN 1420-3049
YR 2022
FD 2022-10
LK http://hdl.handle.net/10498/28808
UL http://hdl.handle.net/10498/28808
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026