RT journal article
T1 Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies
A1 Corral, Ana
A1 Alcalá, Martin
A1 Durán Ruiz, María del Carmen
A1 Arroba Espinosa, Ana Isabel
A1 Ponce González, Jesús Gustavo
A1 Todorčević, Marijana
A1 Serra, Dolors
A1 Calderón Domínguez, María
A1 Herrero, Laura
A2 BiomedicinaBiotecnología y Salud Pública
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 lncRNA
K1 Adipose tissue
K1 Biomarkers
K1 Obesity
K1 Diabetes
K1 Therapeutics
AB The incidence of obesity and its related disorders has increased dramatically in recent years and has become a pandemic. Adipose tissue is a crucial regulator of these diseases due to its endocrine capacity. Thus, understanding adipose tissue metabolism is essential to finding new effective therapeutic approaches. The "omic" revolution has identified new concepts about the complexity of the signaling pathways involved in the pathophysiology of adipose tissue-associated disorders. Specifically, advances in transcriptomics have allowed its application in clinical practice and primary or secondary prevention. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of adipose tissue since they can modulate gene expression at the epigenetic, transcriptional, and post-transcriptional levels. They interact with DNA, RNA, protein complexes, other noncoding RNAs, and microRNAs to regulate a wide range of physiological and pathological processes. Here, we review the emerging field of lncRNAs, including how they regulate adipose tissue biology, and discuss circulating lncRNAs, which may represent a turning point in the diagnosis and treatment of adipose tissue-associated disorders. We also highlight potential biomarkers of obesity and diabetes that could be considered as therapeutic targets.
PB ELSEVIER
SN 1873-2968
YR 2022
FD 2022-12
LK http://hdl.handle.net/10498/28811
UL http://hdl.handle.net/10498/28811
LA eng
NO This study was supported by the Spanish Ministry of Science and Innovation (MCIN) (PID2020-114953RB-C21 to LH and DS, co-funded by the European Regional Development Fund [ERDF], PID2020-114343GA-100 to MA, and PID2019-110063RA-I00 to JP and MC), the Biomedical Research Centre in Pathophysiology of Obesity and Nutrition (CIBEROBN) (Grant CB06/03/0001 to LH), and the Merck Health Foundation (to LH). AC is a recipient of the Formación de Personal Investigador (FPI) doctoral fellowship from the MCIN.‬‬‬‬‬‬ We thank MCarmen Soler-Vázquez for her expert assistance in the preparation of Fig. 1 .
DS Repositorio Institucional de la Universidad de Cádiz
RD 22-sep-2026