RT journal article T1 Analysis of psychoactive substances and metabolites in sludges, soils, sediments and biota: a review A1 Santana Viera, Sergio A1 Pintado Herrera, Marina Guadalupe A1 Sosa Ferrera, Zoraida A1 Santana Rodríguez, José Juan A2 Química Física K1 Solid matrix K1 Ultrasonic-assisted extraction K1 Pressurised liquid extraction K1 Microwave-assisted extraction K1 Illicit drugs K1 Psychoactive compounds AB The use of psychoactive substances, including illegal drugs, drugs of abuse and psychiatric pharmaceuticals, is a major healthand environmental issue. In particular, drugs are found in urban sewage and water ecosystems. The analysis of drugs inwastewater is challenging because drugs occur at trace levels in complex organo-mineral media, calling for advanced analytical methods. Here we review recent methods developped to analyze drugs in sludge, sediments, soils and biota. Extractionmethods include solid–liquid extraction, sonication, microwave, and quick, easy, cheap, efective, rugged and safe extraction (QuEChERS). We compare and discuss advantages and disadvantages of each analytical step for various sample types. PB Springer SN 1610-3653 YR 2023 FD 2023-03 LK http://hdl.handle.net/10498/28900 UL http://hdl.handle.net/10498/28900 LA eng NO Funding for open access publishing: Universidad de Cádiz/CBUA. Sergio Santana-Viera thanks the University of Cádiz for his research contract (FEDER-UCA18-107036). DS Repositorio Institucional de la Universidad de Cádiz RD 21-sep-2026