RT journal article
T1 Significance of cell adhesion molecules profile during pregnancy in gestational diabetes mellitus. A systematic review and meta-analysis
A1 Roca Rodríguez, María del Mar
A1 Ramos García, Pablo
A1 López Tinoco, Cristina
A1 Aguilar Diosdado, Manuel
A1 Roca Rodríguez, María del Mar
A2 Medicina
K1 Cell adhesion molecules
K1 Gestational diabetes mellitus
K1 Materno-fetal outcomes
K1 Meta-analysis
K1 Systematic review
K1 Umbilical cord
AB Endothelial dysfunction has been considered as a key etiological factor contributed to the development of vascular disease in diabetes mellitus. Serum level of endothelial cell adhesion molecules (AMs) were reported to be increased in GDM and pregnant women with normal glucose tolerance when compared with nonpregnant women. The literature provides limited evidence of endothelial dysfunction in GDM with heterogeneous and contradictory results respect to their possible involvement in maternal, perinatal and future complications. Our objective is to evaluate current evidence on the role of AMs in maternal and perinatal complications in women with GDM. PubMed, Embase, Web of Science, and Scopus databases were searched. We evaluated the studies’ quality using the Newcastle-Ottawa scale. Meta-analyses were conducted, and heterogeneity and publication bias were examined. Nineteen relevant studies were finally included, recruiting 765 GDM and 2368 control pregnant women. AMs levels were generally higher in GDM participants showing statistical significance maternal ICAM-1 levels (SMD = 0.58, 95% CI = 0.25 to 0.91; p = 0.001). Our meta-analysis did not detect significant differences in subgroups or in meta-regression analyses. Future studies are needed to establish the potential role of these biomarkers in GDM and its complications.
PB Elsevier
SN 0168-8227
YR 2023
FD 2023-06-03
LK http://hdl.handle.net/10498/28966
UL http://hdl.handle.net/10498/28966
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026