RT journal article
T1 Estimating the heating of complex nanoparticle aggregates for magnetic hyperthermia
A1 Ortega Ponce, Daniel
A1 Ortega Julia, Javier
A1 Leliaert, Jonathan
A2 Física de la Materia Condensada
K1 Hyperthermia therapy
K1 magnetic nanoparticles
K1 Particle size analysis
AB Understanding and predicting the heat released by magnetic nanoparticles is central to magnetic hyperthermia treatment planning. In most cases, nanoparticles form aggregates when injected in living tissues, thereby altering their response to the applied alternating magnetic field and preventing the accurate prediction of the released heat. We performed a computational analysis to investigate the heat released by nanoparticle aggregates featuring different sizes and fractal geometry factors. By digitally mirroring aggregates seen in biological tissues, we found that the average heat released per particle stabilizes starting from moderately small aggregates, thereby facilitating making estimates for their larger counterparts. Additionally, we studied the heating performance of particle aggregates over a wide range of fractal parameters. We compared this result with the heat released by non-interacting nanoparticles to quantify the reduction of heating power after being instilled into tissues. This set of results can be used to estimate the expected heating in vivo based on the experimentally determined nanoparticle properties.
PB The Royal Society of Chemistry
SN 2040-3372
YR 2023
FD 2023-06-23
LK http://hdl.handle.net/10498/29131
UL http://hdl.handle.net/10498/29131
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026