RT journal article
T1 The influence of massive jejunectomy on endocrine pancreas of diabetic Goto-Kakizaki
T2 La influencia de las resecciones masivas intestinales sobre el páncreas endocrino de ratas diabéticas Goto-Kakizaki
A1 Camacho Ramírez, Alonso
A1 Mayo Ossorio, María de los Ángeles
A1 Pacheco García, José Manuel
A1 Carrasco Molinillo, María del Carmen
A1 Fernández Vivero, José
A1 Almorza Gomar, David
A1 Ribelles García, Antonio
A1 Prada Oliveira, José Arturo
A1 Pérez Arana, Gonzalo Martín
A2 Anatomía y Embriología Humana
A2 Cirugía
A2 Estadística e Investigación Operativa
K1 Bariatric-surgery
K1 Beta-cell mass
K1 Diabetes
K1 Insulin-secreting cells
K1 Pancreas
K1 Diabetes
K1 Cirugía bariátrica
K1 Células secretoras de insulina
K1 Masa celular beta
AB Objective: Several bariatric surgeries have been related to the T2DM improvement in obese patients. Despite the different mechanism invoked for this improvement, many evidences showed that the pancreas cellularity is conditioned for the homeostatic physiological changes after these surgeries. Many authors reported the changes in beta-cell mass after some surgeries in healthy rats. We purpose to analyze the changes in b-cell cellularity and b-cell-mass after a severe malabsorptive surgical method. Thus, we studied several parameters of the islet morphometric composition after a massive jejunal resection. Materials and methods: We employed Goto-Kakizaki diabetic non-obese rats, which underwent the 50% resection of middle portion of the jejunum versus a control group. After 3 months, rats were sacrificed and pancreas was immunohistochemicaly studied. Results: The b-cell mass was analyzed and several parameters about the endocrine islet size distribution were studied. We report an increase of b-cell mass in massive resection surgical group versus controls. The islet distribution was significant different between both groups. Endocrine islets of surgical group were bigger with a different cellular distribution. Conclusion: According to the enteroendocrine changes related to surgeries in jejunum, as in other gastrointestinal portions, the cellularity of islets changes as an adaptive process to glycemic demands.
PB Academic Mexicana de Cirugia
SN 0009-7411
YR 2022
FD 2022-09
LK http://hdl.handle.net/10498/29357
UL http://hdl.handle.net/10498/29357
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026