RT journal article
T1 Correlation between urinary and serum NT-proBNP in acute bronchiolitis: A pilot study
A1 Rodríguez González, Moisés
A1 Estepa Pedregosa, Lorena
A1 Calero Ruiz, María Mercedes
A1 Castellano Martinez, Ana
A1 Estalella Mendoza, Ana
A1 Sáez-Benito Godino, Ana
A1 Flores González, José Carlos
A1 Rodriguez-Campoy, Patricia
A2 BiomedicinaBiotecnología y Salud Pública
A2 Materno-Infantil y Radiología
K1 acute bronchiolitis
K1 biomarkers
K1 infections
K1 pneumonia
K1 myocardial strain
K1 natriuretic peptides
K1 pulmonary hypertension
K1 urinary NT-proBNP
K1 viral
AB Background and Aims: We aimed to analyze the correlation of urinary with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and its association with severity in acute bronchiolitis. Material and Methods: A pilot observational study was conducted between October 1, 2021 and March 31, 2022 including acute bronchiolitis cases who attended our institution. Serum and urinary NT-proBNP concentrations were determined using the Alere i NT-proBNP assay in time-matched urine and blood samples. The Mann−Whitney U test, Spearman's correlations, and simple linear regression were utilized to analyze the association of urine NT-proBNP levels with serum NT-proBNP and with variables indicative of severe bronchiolitis. Results: Seventeen infants (median age 68 [IQR: 36−91] days) with 36 time-matched samples were included. The urine NT-proBNP was positively and strongly correlated with the serum NT-proBNP concentrations (Spearman's ρ = 0.81 & R2 coefficient = 0.751; p < 0.001), and increased with higher C-reactive protein, (p = 0.004), procalcitonin (p = 0.001), and pCO2 (p = 0.029) levels. The initial urinary NT-proBNP concentrations were higher in those infants that required ventilatory support compared with those without this outcome (1.85 [IQR: 1.16−2.44] vs. 0.63 [IQR: 0.45−0.84] pg/mg); p < 0.001); and resulted positively and strongly correlated with the duration of the ventilatory support (Spearman's ρ = 0.76; p < 0.001) and the length of stay hospitalization (Spearman's ρ = 0.84; p < 0.001). Conclusion: The urinary NT-proBNP concentrations could be a reliable surrogate for serum NT-proBNP levels and resulted elevated in cases of acute bronchiolitis with complicated evolution, suggesting a potential as a noninvasive tool to assess severity in this setting
PB Wiley
SN 8755-6863
YR 2022
FD 2022-10-31
LK http://hdl.handle.net/10498/29382
UL http://hdl.handle.net/10498/29382
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026