RT journal article
T1 Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques
A1 Yeste Siguenza, María del Pilar
A1 Fernández Ponce, Cecilia Matilde
A1 Félix Ruiz, Eduardo José
A1 Tinoco Rivas, Miguel
A1 Fernandez-Cisnal, Ricardo
A1 García Villar, Cristina
A1 Pfaff, C
A1 Kriwet, J
A1 Natividad, E.
A1 Cauqui López, Miguel Ángel
A1 García Cózar, Francisco José
A1 Litrán Ramos, Rocío
A1 Bomati Miguel, Óscar
A2 BiomedicinaBiotecnología y Salud Pública
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
A2 Física de la Materia Condensada
A2 Materno-Infantil y Radiología
K1 Ytterbium-iron nanoparticles
K1 Functionalization
K1 Multiplatform contrast agents
K1 Solvothermal process
K1 computerized tomography (CT)
K1 Magnetic Resonance Imaging (MRI)
AB A solvothermal route to prepare Glutathione capped hybrid ytterbium/iron oxide nanoparticles with potential applications as multiplatform contrast agent in medical image techniques has been developed. The influence of ytterbium/iron molar ratio used as precursor, as well as the degree of the autoclave filling on the structural and morphological characteristics of the obtained nanoparticles has been extensively studied. Although all nanoparticles present similar composition, with YbFeO3 being the majority phase, size and morphology of the as synthetized nanoparticles are highly influenced by the critical temperature and by the over -saturation reached during the solvothermal process. We have demonstrated that glutathione properly functionalizes the hybrid nanoparticles, increasing their colloidal stability and decreasing their cytotoxicity. Additionally, they show good imaging in magnetic resonance and X-ray computerized tomography, thereby indicating promising potential as a dual contrast agent. This work presents, for the first time, glutathione functionalized ytterbium/iron oxide nanoparticles with potential applications in Biomedicine.
PB Elsevier
SN 0272-8842
YR 2023
FD 2023-06-26
LK http://hdl.handle.net/10498/29420
UL http://hdl.handle.net/10498/29420
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026