RT journal article
T1 Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study
A1 Bermejo Martin, Jesús F.
A1 García Mateo, Nadia
A1 Motos, Anna
A1 Resino, Salvador
A1 Tamayo, Luis
A1 Ryan Murua, Pablo
A1 Bustamante Munguira, Elena
A1 Gallego Curto, Elena
A1 Úbeda Iglesias, Alejandro
A1 de la Torre, María del Carmen
A1 Estella García, Ángel
A1 Campos Fernández, Sandra
A1 Martínez Varela, Ignacio
A1 Pérez García, Felipe
A1 Socias, Lorenzo
A1 López Messa, Juan
A1 Vidal Cortés, Pablo
A1 Sagredo Meneses, Víctor
A1 González Rivera, Milagros
A1 Carbonell, Nieves
A1 de Gonzalo Calvo, David
A1 Martín Delgado, María Cruz
A1 Valdivia, Luis Jorge
A1 Martín López, Caridad
A1 Jorge García, Ruth Noemí
A1 Maseda, Emilio
A1 Loza Vázquez, Ana
A1 Kelvin, David J.
A1 Barbé, Ferrán
A1 Torres, Antoni
A1 Ortega, Alicia
A1 de la Fuente, Amanda
A1 Almansa, Raquel
A1 Postigo, Tamara
A1 Jorge, Noelia
A1 Tedim, Ana P.
A1 González González, Laura
A1 Sánchez Recio, Lara
A1 Trapiello, Wysali
A1 Berezo, José Ángel
A1 Herrán Monge, Rubén
A1 Blanco, Jesús
A1 Enríquez, Pedro
A1 Martínez, Isidoro
A1 Martín Vicente, María
A1 Muñoz Gómez, María José
A1 Más, Vicente
A1 Vázquez, Mónica
A1 Cano, Olga
A1 Martínez de la Gándara, Amalia
A1 Rodríguez, Covadonga
A1 Andrade, Gloria
A1 Renedo, Gloria
A1 Bustamante Munguira, Juan
A1 Cicuendez Ávila, Ramón
A1 Salgado Villén, María
A1 Berruguilla Pérez, Enrique
A1 Güell, Estel
A1 Casadiego Monachello, Fernando Javier
A1 Recuerda Núñez, María
A1 Sánchez Calvo, Juan Manuel
A1 Peñasco Martín, Yhivian
A1 García Unzueta, María Teresa
A1 Ceccato, Adrián
A1 Fernández Barat, Laia
A1 Bouza Vieiro, María Teresa
A1 Moreno Romero, Ana
A1 Pérez Bastida, Leire
A1 del Río Carbajo, Lorena
A1 Albalá Martínez, Noelia
A1 Gómez, José Manuel
A1 Blasco, María Luisa
A1 Caballero, Jesús
A1 Barberà, Carme
A1 González, Jessica
A1 Nieto, María Teresa
A1 Nieto del Olmo, Jorge
A1 Prol Silva, Estefanía
A1 Canseco Ribas, Joan
A1 Eiros, Jose María
A2 BiomedicinaBiotecnología y Salud Pública
A2 Medicina
K1 COVID-19
K1 viral R  load
K1 cause death
AB Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero ([removed]2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16–0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26–0·57; p[removed]
PB Elsevier
SN 2666-5247
YR 2023
FD 2023-04-25
LK http://hdl.handle.net/10498/29593
UL http://hdl.handle.net/10498/29593
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 04-nov-2026