RT journal article
T1 Autosomal dominant polycystic kidney disease in young adults
A1 Martínez, Víctor
A1 Furlano, Mónica
A1 Sans, Laia
A1 Pulido, Lissett
A1 García, Rebeca
A1 Pérez Gómez, María Vanessa
A1 Sánchez Rodríguez, Jinny
A1 Blasco, Miquel
A1 Castro Alonso, Cristina
A1 Fernández Fresnedo, Gema
A1 Roberto Robles, Nicolás
A1 Valenzuela, María Pau
A1 Naranjo Muñoz, Javier
A1 Martín, Nadia
A1 Pilco, Melissa
A1 Agraz Pamplona, Irene
A1 González Rodríguez, Juan David
A1 Panizo, Nayara
A1 Fraga, Gloria
A1 Fernández, Loreto
A1 López, María Teresa
A1 Dall’Anese, Cecilia
A1 Ortiz, Alberto
A1 Torra, Roser
A2 Medicina
K1 ADKPD
K1 children
K1 glomerular filtration rate
K1 hypertension
K1 young adults
AB Background The clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD) usually appear in adulthood, however pediatric series report a high morbidity. The objective of the study was to analyze the clinical characteristics of ADPKD in young adults. Methods Family history, hypertension, albuminuria, estimated glomerular filtration rate (eGFR) and imaging tests were examined in 346 young adults (18-30 years old) out of 2521 patients in the Spanish ADPKD registry (REPQRAD). A literature review searched for reports on hypertension in series with more than 50 young (age <30 years) ADPKD patients. Results The mean age of this young adult cohort was 25.24 (SD 3.72) years. The mean age at diagnosis of hypertension was 21.15 (SD 4.62) years, while in the overall REPQRAD population was aged 37.6 years. The prevalence of hypertension was 28.03% and increased with age (18-24 years, 16.8%; 25-30 years, 36.8%). Although prevalence was lower in women than in men, the age at onset of hypertension (21 years) was similar in both sexes. Mean eGFR was 108 (SD 21) mL/min/1.73 m(2), 38.0% had liver cysts and 3.45% of those studied had intracranial aneurysms. In multivariate analyses, hematuria episodes and kidney length were independent predictors of hypertension (area under the curve 0.75). The prevalence of hypertension in 22 pediatric cohorts was 20%-40%, but no literature reports on hypertension in young ADPKD adults were found. Conclusions Young adults present non-negligible ADPKD-related morbidity. This supports the need for a thorough assessment of young adults at risk of ADPKD that allows early diagnosis and treatment of hypertension. Lay Summary Impairment of renal function usually develops from the fourth decade of life in autosomal dominant polycystic kidney disease (ADPKD). However, hypertension precedes the onset of renal insufficiency. In published pediatric series, the prevalence of hypertension is 20%-40%. However, clinical information on young adults with ADPKD is scarce. We present the largest cohort of young adults (age 18-30 years) with ADPKD published to date. Prevalence of hypertension is 28% and increases with age, reaching 36.8% in the subgroup aged 25-30 years, despite normal glomerular filtration rate and albuminuria. The prevalence of hypertension is higher in males, but the mean age at diagnosis (21 years) was similar in both sexes. Young adults present non-negligible ADPKD-related morbidity. This supports the need for a thorough assessment that allows early diagnosis and treatment of hypertension, before decline of estimated glomerular filtration rate. Ambulatory blood pressure monitoring may be especially useful in this regard.
PB Oxford University Press
SN 2048-8505
YR 2022
FD 2022-11-29
LK http://hdl.handle.net/10498/29677
UL http://hdl.handle.net/10498/29677
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 13-nov-2026