RT journal article
T1 Accelerometer-measured intensity-specific physical activity, genetic risk and incident type 2 diabetes: A prospective cohort study
A1 Luo, Mengyun
A1 Yu, Chenhao
A1 Pozo Cruz, Borja del
A1 Chen, Liangkai
A1 Ding, Ding
A1 ding
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 endocrine system
K1 epidemiology
K1 genetics
K1 physical activity
K1 preventive medicine
AB Objective Although 30 min/day of moderate-intensity physical activity is suggested for preventing type 2 diabetes (T2D), the current recommendations exclusively rely on self-reports and rarely consider the genetic risk. We examined the prospective dose-response relationships between total/intensity-specific physical activity and incident T2D accounting for and stratified by different levels of genetic risk. Methods This prospective cohort study was based on 59 325 participants in the UK Biobank (mean age=61.1 years in 2013-2015). Total/intensity-specific physical activity was collected using accelerometers and linked to national registries until 30 September 2021. We examined the shape of the dose-response association between physical activity and T2D incidence using restricted cubic splines adjusted for and stratified by a polygenic risk score (based on 424 selected single nucleotide polymorphisms) using Cox proportional hazards models. Results During a median follow-up of 6.8 years, there was a strong linear dose-response association between moderate-to-vigorous-intensity physical activity (MVPA) and incident T2D, even after adjusting for genetic risk. Compared with the least active participants, the HRs (95% CI) for higher levels of MVPA were: 0.63 (0.53 to 0.75) for 5.3-25.9 min/day, 0.41 (0.34 to 0.51) for 26.0-68.4 min/day and 0.26 (0.18 to 0.38) for >68.4 min/day. While no significant multiplicative interaction between physical activity measures and genetic risk was found, we found a significant additive interaction between MVPA and genetic risk score, suggesting larger absolute risk differences by MVPA levels among those with higher genetic risk. Conclusion Participation in physical activity, particularly MVPA, should be promoted especially in those with high genetic risk of T2D. There may be no minimal or maximal threshold for the benefits. This finding can inform future guidelines development and interventions to prevent T2D.
PB BMJ
SN 0306-3674
YR 2023
FD 2023-06-05
LK http://hdl.handle.net/10498/29721
UL http://hdl.handle.net/10498/29721
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 09-may-2026