RT journal article
T1 New Eremophilane-Type Sesquiterpenes from the Marine Sediment-Derived Fungus Emericellopsis maritima BC17 and Their Cytotoxic and Antimicrobial Activities
A1 Roca Virués de Segovia, Jorge
A1 Millán, Carlos
A1 Pinedo Rivilla, Cristina
A1 González Rodríguez, Victoria Eugenia
A1 Papaspyrou, Sokratis
A1 Zorrilla Cuenca, David
A1 Mackenzie, Thomas A
A1 Ramos, María C.
A1 Cruz, Mercedes de la
A1 Aleu Casatejada, Josefina
A1 Durán Patrón, Rosa María
A2 Química Orgánica
K1 Emericellopsis maritima
K1 marine-derived fungus
K1 OSMAC strategy
K1 eremophilanes
K1 diketopiperazines
K1 cytotoxicity
K1 antibacterial
K1 antifungal
AB The fungal strain BC17 was isolated from sediments collected in the intertidal zone of the inner Bay of Cadiz and characterized as Emericellopsis maritima. On the basis of the one strain–many compounds (OSMAC) approach, four new eremophilane-type sesquiterpenes (1–4), together with thirteen known derivatives (5–17) and two reported diketopiperazines (18, 19), were isolated from this strain. The chemical structures and absolute configurations of the new compounds were determined through extensive NMR and HRESIMS spectroscopic studies and ECD calculation. Thirteen of the isolated eremophilanes were examined for cytotoxic and antimicrobial activities. PR toxin (16) exhibited cytotoxic activity against HepG2, MCF-7, A549, A2058, and Mia PaCa-2 human cancer cell lines with IC50 values ranging from 3.75 to 33.44 µM. (+)-Aristolochene (10) exhibited selective activity against the fungal strains Aspergillus fumigatus ATCC46645 and Candida albicans ATCC64124 at 471 µM.
PB MDPI
YR 2023
FD 2023
LK http://hdl.handle.net/10498/29853
UL http://hdl.handle.net/10498/29853
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 05-nov-2026