RT journal article
T1 Resistance modulatory and efflux-inhibitory activities of capsaicinoids and capsinoids
A1 Prasch, Sandra
A1 García Durán, Alexandra
A1 Chinchilla Salcedo, Nuria
A1 González Molinillo, José María
A1 Macías Domínguez, Francisco Antonio
A1 Bucar, Franz
A2 Química Orgánica
K1 Capsaicinoids
K1 Capsinoids
K1 Efflux pump inhibitor
K1 Resistance
K1 Mycobacteria
AB Capsaicinoids are reported to have a bunch of promising pharmacological activities, among them antibacterial effects against various strains of bacteria. In this study the effect on efflux pumps of mycobacteria was investigated. The importance of efflux pumps, and the inhibition of these, is rising due to their involvement in antibiotic resistance development. In order to draw structure and activity relationships we tested natural and synthetical capsaicinoids as well as synthetical capsinoids. In an accumulation assay these compounds were evaluated for their ability to accumulate ethidium bromide into mycobacterial cells, a well-known substrate for efflux pumps. Capsaicin and dihydrocapsaicin, the two most abundant capsaicinoids in Capsicum species, proved to be superior efflux pump inhibitors compared to the standard verapamil. A dilution series showed dose dependency of both compounds. The compound class of less pungent capsinoids qualified for further investigation as antibacterials against Mycobacterium smegmatis.
PB Elsevier
SN 0045-2068
YR 2019
FD 2019
LK http://hdl.handle.net/10498/29915
UL http://hdl.handle.net/10498/29915
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026