RT journal article
T1 Biological Activity of Naphthoquinones Derivatives in the Search of Anticancer Lead Compounds
A1 García Durán, Alexandra
A1 Chinchilla Salcedo, Nuria
A1 Simonet Morales, Ana María
A1 Gutiérrez Amares, María Teresa
A1 Bolívar Pérez, Jorge
A1 Martínez Valdivia, Manuel Jesús
A1 González Molinillo, José María
A1 Macías Domínguez, Francisco Antonio
A2 BiomedicinaBiotecnología y Salud Pública
A2 Materno-Infantil y Radiología
A2 Química Orgánica
K1 naphthoquinones
K1 cytotoxic activity
K1 juglone
K1 lawsone
K1 flow cytometry
AB Naphthoquinones are a valuable source of secondary metabolites that are well known fortheir dye properties since ancient times. A wide range of biological activities have been describedhighlighting their cytotoxic activity, gaining the attention of researchers in recent years. In addition,it is also worth mentioning that many anticancer drugs possess a naphthoquinone backbone in theirstructure. Considering this background, the work described herein reports the evaluation of thecytotoxicity of different acyl and alkyl derivatives from juglone and lawsone that showed the bestactivity results from a etiolated wheat coleoptile bioassay. This bioassay is rapid, highly sensitive to awide spectrum of activities, and is a powerful tool for detecting biologically active natural products.A preliminary cell viability bioassay was performed on cervix carcinoma (HeLa) cells for 24 h. Themost promising compounds were further tested for apoptosis on different tumoral (IGROV-1 andSK-MEL-28) and non-tumoral (HEK-293) cell lines by flow cytometry. Results reveal that derivativesfrom lawsone (particularly derivative 4) were more cytotoxic on tumoral than in non-tumoral cells,showing similar results to those obtained with of etoposide, which is used as a positive control forapoptotic cell death. These findings encourage further studies on the development of new anticancerdrugs for more directed therapies and reduced side effects with naphthoquinone skeleton.
PB MDPI
SN 2072-6651
YR 2023
FD 2023-05-20
LK http://hdl.handle.net/10498/30042
UL http://hdl.handle.net/10498/30042
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 06-nov-2026