RT journal article
T1 Effect of lead on ALA-D activity, metallothionein levels, and lipid peroxidation in blood, kidney, and liver of the toadfish Halobatrachus didactylus
A1 Campana, Olivia
A1 Sarasquete Reiriz, María del Carmen
A1 Blasco, Julián
A2 Química Física
AB The effects of lead (Pb) on ALA-D activity, metallothionein (MT) levels, and lipid peroxidation in liver, kidney, and blood of the toadfish Halobatrachus didactylus were investigated. A time-course experiment was performed with sampling on days 0, 2, 5, and 7 following intraperitoneal Pb injection. This indicated a rank order for lead concentration of kidney>liver>blood in fish exposed to Pb. No significant variation of ALA-D activity was observed in liver and kidney while in blood, a slight decrease of ALA-D activity was found but this was not attributed to acute metal stress. Hepatic and renal MT levels were both affected in different ways by metal uptake. The progressive decrease of MDA concentration in the liver and the lack of a clear induction in kidney suggested the hypothesis that Pb is not a good inductor of lipid peroxidation. The histological and histochemical results demonstrated degenerative effects of lead accumulation on the tissues and the activation of lysosomal responses to induced stress.
PB Elsevier
SN 0147-6513
YR 2003
FD 2003
LK http://hdl.handle.net/10498/30061
UL http://hdl.handle.net/10498/30061
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026