RT journal article
T1 Association of Socioeconomic Status and Brain Injury With Neurodevelopmental Outcomes of Very Preterm Children
A1 Benavente Fernández, Isabel
A1 Synnes, Anne
A1 Grunau, Ruth E.
A1 Chau, Vann
A1 Ramraj, Chantel
A1 Glass, Torin
A1 Cayam-Rand, Dalit
A1 Siddiqi, Arjumand
A1 Miller, Steven P.
A2 Materno-Infantil y Radiología
K1 nivel socioeconómico
K1 pretérmino
K1 pronóstico neurológico
AB Importance  Studies of socioeconomic status and neurodevelopmental outcome in very preterm neonates have not sensitively accounted for brain injury.Objective  To determine the association of brain injury and maternal education with motor and cognitive outcomes at age 4.5 years in very preterm neonates.Design, Setting, and Participants  Prospective cohort study of preterm neonates (24-32 weeks’ gestation) recruited August 16, 2006, to September 9, 2013, at British Columbia Women's Hospital in Vancouver, Canada. Analysis of 4.5-year outcome was performed in 2018.Main Outcomes and Measures  At age 4.5 years, full-scale IQ assessed using the Wechsler Primary and Preschool Scale of Intelligence, Fourth Edition, and motor outcome by the percentile score on the Movement Assessment Battery for Children, Second Edition.Results  Of 226 survivors, neurodevelopmental outcome was assessed in 170 (80 [47.1%] female). Based on the best model to assess full-scale IQ accounting for gestational age, standardized β coefficients demonstrated the effect size of maternal education (standardized β = 0.21) was similar to that of white matter injury volume (standardized β = 0.23) and intraventricular hemorrhage (standardized β = 0.23). The observed and predicted cognitive scores in preterm children born to mothers with postgraduate education did not differ in those with and without brain injury. The best-performing model to assess for motor outcome accounting for gestational age included being small for gestational age, severe intraventricular hemorrhage, white matter injury volume, and chronic lung disease.Conclusions and Relevance  At preschool age, cognitive outcome was comparably associated with maternal education and neonatal brain injury. The association of brain injury with poorer cognition was attenuated in children born to mothers of higher education level, suggesting opportunities to promote optimal outcomes.
PB JAMA Network Open
SN 2574-3805
YR 2019
FD 2019-05-03
LK http://hdl.handle.net/10498/30255
UL http://hdl.handle.net/10498/30255
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026