RT journal article
T1 Immune modulation by the hepatitis C virus core protein
A1 Fernández Ponce, Cecilia Matilde
A1 Domínguez Villar, Margarita
A1 Muñoz Miranda, Juan Pedro
A1 Martínez de Arbulo Echevarría, Miguel
A1 Litrán Ramos, Rocío
A1 Aguado Vidal, Enrique
A1 García Cózar, Francisco José
A2 BiomedicinaBiotecnología y Salud Pública
A2 Física de la Materia Condensada
K1 exhausted phenotype
K1 HCV
K1 immune evasion
K1 immune tolerance
K1 regulatory T cells
AB Hepatitis C virus (HCV) infection is currently the most important cause of chronic viralhepatitis in the world and one of the most frequent indications for liver transplantation.HCV uses different strategies to evade the innate and adaptive immune response,and this evasion plays a key role in determining viral persistence. Several HCV viralproteins have been described as immune modulators. In this review, we will focus onthe effect of HCV nucleocapsid core protein in the function of immune cells and itscorrelation with the findings observed in HCV chronically infected patients. Effects onimmune cell function related to both extracellular and intracellular HCV core localizationwill be considered. This review provides an updated perspective on the mechanismsinvolved in HCV evasion related to one single HCV protein, which could becomea key tool in the development of new antiviral strategies able to control and/or eradicateHCV infection.
PB WILEY
SN 1365-2893
YR 2017
FD 2017-04-21
LK http://hdl.handle.net/10498/30350
UL http://hdl.handle.net/10498/30350
LA eng
NO Ministerio de Educación y Ciencia (España) (SAF2009-09449); Consejería de Salud de la Junta de Andalucía (SAS 111206)
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026