RT journal article
T1 Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves
A1 Simonet Morales, Ana María
A1 Silva, Naiara C.
A1 Dias, Amanda L.T.
A1 Vilegas, Wagner
A1 Macías Domínguez, Francisco Antonio
A1 Dias Silva, Marcelo J.
A2 Química Orgánica
K1 Mimosa caesalpiniifolia
K1 fungistatic
K1 flavonoids
K1 synergistic interaction
AB A bioassay-guided phytochemical study of a Mimosa caesalpiniifolia leaf extract with antifungal activitypermitted the identification of 28 compounds, including the new 6-(β-boivinopyranosyl)apigenin (1), 8-(β-oliopyranosyl)-apigenin (2), (E)-6-(2-carboxyethenyl)apigenin (3), (E)-8-(2-carboxyethenyl)apigenin (4), and 7,5″-anhydro-6-(α-2,6-dideoxy-5-hydroxyarabinohexopyranosyl)apigenin (5). The structures of the new compounds were determined by comprehensive spectroscopic analysis, including 1D and 2DNMR techniques, and by mass spectrometry. Compound 3 showed promising activity and selectivity against Candida krusei (IC50 44 nM), which exhibits resistance to azoles. The association of the major components 3-β-D-glucopyranosyloxysitosterol (8) and ethyl gallate (10) was synergistic against C.krusei, especially the IC values of compound 10, which were reduced by more than 100-fold.
PB AMER CHEMICAL SOC
SN 1520-6025
YR 2019
FD 2019-06-18
LK http://hdl.handle.net/10498/30395
UL http://hdl.handle.net/10498/30395
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026