RT journal article
T1 Lathyrane, Premyrsinane and Related Diterpenes from Euphorbia boetica: Effect on in Vitro Neural Progenitor Cell Proliferation
A1 Flores Giubi, Eugenia
A1 Geribaldi Doldán, Noelia
A1 Murillo Carretero, Maribel
A1 Castro González, Carmen
A1 Durán Patrón, Rosa María
A1 Macías Sánchez, Antonio José
A1 Hernández Galán, Rosario
A2 Anatomía y Embriología Humana
A2 BiomedicinaBiotecnología y Salud Pública
A2 Química Orgánica
K1 Diterpenes
K1 Euphorbia boetica
K1 Neural Progenitor Cell Proliferation
AB Lathyrane-type diterpenes previously have been proven to promote proliferation of neural precursorcells (NPCs) by targeting and activating one or more protein kinase C (PKC) isozymes. Aiming to find new drug candidates with a lathyrane skeleton to modulate adult neurogenesis through PKC activation, a phytochemical study of a methanol extract of the aerial parts of Euphorbia boetica was carried out.Seven new diterpenes, representing the premyrsinane (1−3), myrsinane (4, 5), and cyclomyrsinane  types (6, 7), along with three known diterpenes, belonging to the cyclomyrsinane (8)and lathyrane types (9, 10), were isolated. The chemical structures and relative configurations of the new compounds were determined by extensive NMR spectroscopic studies and comparison with known compounds. The absolute configurations for compounds 2, 3, 6, and 7 were proposed, based on a comparison of the experimental ECD spectra of compounds 2 and 7 with those of known related compounds. The activity of lathyrane compounds 9 and 10 as promoters of NPC proliferation was evaluated using a neurosphere assay. Both compounds increased the size of neurospheres in a dose-dependent manner when proliferation was stimulated by the epidermal growth factor and the basic fibroblast growth factor.
PB American Chemical Society and American Society of Pharmacognosy.
SN 1520-6025
YR 2019
FD 2019-09-11
LK http://hdl.handle.net/10498/30449
UL http://hdl.handle.net/10498/30449
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026