RT journal article
T1 Chromosome-level genome of the venomous snail Kalloconus canariensis: a valuable model for venomics and comparative genomics
A1 Herráez-Pérez, Ana
A1 Pardos-Blas, José R.
A1 Afonso, CarlosM.L
A1 Jiménez Tenorio, Manuel
A1 Zardoya, Rafael
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
K1 cone snail
K1 genome
K1 venomics
K1 conotoxin
AB BACKGROUND: Genomes are powerful resources to understand the evolutionary mechanisms underpinning the origin and diversification of the venoms of cone snails (Conidae: Caenogastropoda) and could aid in the development of novel drugs. FINDINGS: Here, we used PacBio continuous long reads and Omni-C data to assemble the chromosome-level genome of Kalloconus canariensis, a vermivorous cone endemic to the Canary Islands. The final genome size was 2.87 Gb, with a N50 of 79.75 Mb and 91% of the reads located into the 35 largest scaffolds. Up to 55.80% of the genome was annotated as repetitive regions, being class I of transposable elements (16.65%) predominant. The annotation estimated 34,287 gene models. Comparative analysis of this genome with the 2 cone snail genomes released to date (Dendroconus betulinus and Lautoconus ventricosus) revealed similar genome sizes and organization, although chromosome sizes tended to be shorter in K. canariensis. Phylogenetic relationships within subclass Caenogastropoda were recovered with strong statistical support. The family Conidae was recovered as a clade, with K. canariensis plus L. ventricosus sister to D. betulinus. CONCLUSIONS: Despite the great diversity of cone snails (>900 species) and their venoms (hundreds of peptides per species), only 2 recently reported genomes are available for the group. The high-quality chromosome-level assembly of K. canariensis will be a valuable reference for studying the origin and evolution of conotoxin genes as well as whole-genome duplication events during gastropod evolution.
YR 2023
FD 2023-09-30
LK http://hdl.handle.net/10498/30466
UL http://hdl.handle.net/10498/30466
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 15-nov-2026