RT journal article T1 The role of fatness on physical fitness in adolescents with and without Down syndrome. The UP&DOWN Study A1 Izquierdo Gómez, Rocío A1 Martínez-Gómez, David A1 Fernhall, Bo A1 Sanz, Alberto A1 Veiga, Oscar A2 Didáctica de la Educación FísicaPlástica y Musical K1 fatness K1 physical fitness K1 Down syndrome AB Background/Objectives: Adolescents with Down syndrome (DS) exhibit higher levels of fatness and low levels of physical fitness compared with those without DS. In adolescents without DS, fatness is tightly associated with physical fitness, but this association is unclear in adolescents with DS. The aim of this study was to examine the association between several markers of fatness and physical fitness in a relative large sample of adolescents with and without DS. Subjects/ Methods: For this study, a total of 111 adolescents with DS (41 females) aged 11 to 20 years old participated in this cross-sectional study. We also included a sex-matched control group (ratio 1:2) of 222 adolescents without DS aged 12 to 18 years old, participating in the UP&DOWN Study. The ALPHA health-related fitness test battery for adolescents was used to assess fatness and physical fitness. Results: Our results show that fatness is not associated with low levels of physical fitness in adolescents with DS (i.e. 3 of the 16 analyses identified differences in physical fitness variables by groups of fatness). In contrast, fatness, as expected, is associated with levels of physical fitness in adolescents without DS (i.e. 13 of the 16 analyses identified differences in physical fitness variables by groups of fatness). Conclusions: The present finding contributes to new knowledge by suggesting that the role of fatness on physical fitness is different in adolescents with and without DS, and consequently, the poor levels of physical fitness in adolescents with DS may be due to its syndrome rather than the high prevalence of obesity from this population. SN 0307-0565 YR 2015 FD 2015-07 LK http://hdl.handle.net/10498/30540 UL http://hdl.handle.net/10498/30540 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 12-nov-2026