RT journal article
T1 Independent and combined associations of physical fitness components with inflammatory biomarkers in children and adolescents.
A1 Delgado-Alfonso, Alváro
A1 Pérez-Bey, Alejandro
A1 Conde de Caveda, Julio
A1 Izquierdo Gómez, Rocío
A1 Esteban-Cornejo, Irene
A1 Gómez-Martínez, Sonia
A1 Marcos, Ascensión
A1 Castro Piñero, José
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 adolescent
K1 children
K1 biomarkers
K1 cardiotrespiratory fitness
AB BackgroundWe aimed to examine the independent and combined associations of cardiorespiratory fitness, muscular fitness, and motor ability with single and clustered inflammatory biomarkers in children and adolescents.MethodsThis study included 503 children and adolescents. Cardiorespiratory fitness, upper- and lower-muscular fitness, and motor ability were assessed using field-based tests. Fasting blood samples were obtained to determine the levels of a set of inflammatory biomarkers. Global physical fitness and clustered inflammatory biomarker scores were computed. Associations between physical fitness and inflammatory biomarkers were analyzed through linear regression. Differences in inflammatory biomarker levels between physical fitness tertiles were tested.ResultsGlobal physical fitness was inversely associated with single and clustered inflammatory biomarkers in children (p < 0.05); and with C-reactive protein, complement factor C4, leptin, and clustered inflammatory biomarkers in adolescents (p < 0.025). Cardiorespiratory fitness and upper-muscular fitness were negatively and independently associated with several single and clustered inflammatory biomarkers in children and adolescents (p < 0.05). Differences were found between the lowest and the highest tertiles of global physical fitness in clustered inflammatory biomarker levels (p < 0.010).ConclusionPhysical fitness was negatively associated with single and clustered inflammatory biomarkers, independently of body mass index. Increasing physical fitness levels in youth might contribute to reduce the cardiovascular risk.
SN 0031-3998
YR 2018
FD 2018-11
LK http://hdl.handle.net/10498/30617
UL http://hdl.handle.net/10498/30617
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 07-nov-2026