RT journal article
T1 Plasma Neurofilament Light Chain in Primary Progressive Aphasia and Related Disorders: Clinical Significance and Metabolic Correlates
A1 Matías-Guiu, JA
A1 Gómez-Pinedo, U
A1 Forero, Lucía
A1 Pytel, V
A1 Cano, F
A1 Moreno-Ramos, T
A1 Cabrera-Martín, MN
A1 Matías-Guiu, J
A1 González Rosa, Javier Jesús
A2 Psicología
K1 Alzheimer’s disease
K1 biomarkers
K1 frontotemporal dementia
K1 neurofilament
K1 positron emission tomography
K1 primary progressive aphasia
AB Background: Primary progressive aphasia (PPA) is a heterogeneous syndrome that is difficult to diagnose at early stages. Plasma neurofilament light chain (NFL) has been proposed as a potential biomarker for PPA.Objective: To examine the diagnostic properties of plasma NFL in PPA and to evaluate its association with clinical stages of the disease and brain metabolism.Methods: Our study included 80 participants (13 with non-fluent, 12 with semantic, and 16 with logopenic variant PPA; 13 with amnestic Alzheimer's disease [AD]; 13 with behavioral variant frontotemporal dementia; and 13 healthy controls). Plasma NFL concentration was measured using a high-sensitivity enzyme-linked immunosorbent assay (ELISA) kit. PET imaging was performed in a subgroup of patients.Results: NFL discriminated patients from controls with an area under the curve of 0.914 (95% CI, 0.843-0.984; p < 0.001) (cut-off: 76.46 pg/mL; 94% sensitivity, 76.9% specificity). There were no significant differences between clinical syndromes (PPA subtypes), the main clinical forms of dementia (frontotemporal dementia and AD), or the expected pathological groups (frontotemporal lobar degeneration-tau [FTLD-tau], FTLD-TDP43, and AD). NFL levels showed weak to moderate correlations with age and functional scale score. We found no significant correlation with the extent of hypometabolism observed on FDG-PET images.Conclusion: Plasma NFL is a non-specific marker of neurodegeneration, and may be helpful in the diagnosis of PPA. However, NFL does not permit differential diagnosis between PPA subtypes and is not correlated with the extent of neurodegeneration.
PB IOS PRESS
SN 1387-2877
YR 2019
FD 2019-11-26
LK http://hdl.handle.net/10498/30690
UL http://hdl.handle.net/10498/30690
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026