RT journal article
T1 Neurophysiological correlates of cognitive disturbances in multiple sclerosis
A1 Leocani, L
A1 González Rosa, Javier Jesús
A1 Comi, G
A2 Psicología
K1 Multiple sclerosis
K1 Cognitive impairment
K1 EEG
K1 ERP
K1 ERD
K1 Coherence
AB Cognitive impairment is common in multiple sclerosis, mostly attributed to involvement of cortico-cortical and cortico-subcortical connections. The latter may be explored using the analysis of bioelectrical activity such as power and coherence of the electroencephalogram at rest and its reactivity to stimulus processing and cognitive activities, such as event-related desynchronization and event-related potentials. Although these methods are very useful for assessing information processing during cognitive tasks and other activities, their value in detecting cognitive impairment concerning sensitivity and specificity needs to be validated and they have been mostly used for understanding the physiopathology of cognitive impairment in different forms and stages of the diseases. Nevertheless, newer applications such as longitudinal monitoring and effects of treatment, although explored only in pilot studies, seem quite promising allowing objective measures potentially useful as secondary endpoints in clinical trials aimed at preserving or improving cognition in MS patients.
PB Springer
SN 1590-1874
YR 2010
FD 2010-11-01
LK http://hdl.handle.net/10498/30719
UL http://hdl.handle.net/10498/30719
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026