RT journal article
T1 Intra- and interhemispheric symmetry of subcortical brain structures: a volumetric analysis in the aging human brain
A1 Gómez Ramírez, Jaime D.
A1 González Rosa, Javier Jesús
A2 Psicología
K1 Aging
K1 Eigenvalues
K1 Hemispheric asymmetry
K1 Laterality
K1 MRI
K1 PCA
AB Here, we address the hemispheric interdependency of subcortical structures in the aging human brain. In particular, we investigated whether subcortical volume variations can be explained by the adjacency of structures in the same hemisphere or are due to the interhemispheric development of mirror subcortical structures in the brain. Seven subcortical structures in each hemisphere were automatically segmented in a large sample of 3312 magnetic resonance imaging (MRI) studies of elderly individuals in their 70s and 80s. We performed Eigenvalue analysis, and found that anatomic volumes in the limbic system and basal ganglia show similar statistical dependency whether considered in the same hemisphere (intrahemispherically) or different hemispheres (interhemispherically). Our results indicate that anatomic bilaterality of subcortical volumes is preserved in the aging human brain, supporting the hypothesis that coupling between non-adjacent subcortical structures might act as a mechanism to compensate for the deleterious effects of aging.
PB Springer Healthcare
SN 1863-2661
YR 2022
FD 2022-05-17
LK http://hdl.handle.net/10498/30721
UL http://hdl.handle.net/10498/30721
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026