RT journal article
T1 Neuropsychological and Neuropsychiatric Features of Chronic Migraine Patients during the Interictal Phase
A1 Lozano Soto, Elena María
A1 Cruz Gómez, Álvaro Javier
A1 Rashid Abdu Rahim López, Raúl
A1 Sanmartino, Florencia Soledad
A1 Espinosa Rosso, Raúl
A1 Forero, Lucía
A1 González Rosa, Javier Jesús
A2 Psicología
K1 chronic migraine
K1 interictal phase
K1 neuropsychiatry
K1 neuropsychological impairment
AB This study aimed to examine the presence of neuropsychological deficits and their relationships with clinical, pharmacological, and neuropsychiatric characteristics in chronic migraine (CM) patients assessed during a headache-free period. We enrolled 39 CM patients (mean age: 45.4 years; male/female ratio: 3/36) and 20 age-, sex-, and education-matched healthy controls (HCs, mean age: 45.5 years; male/female ratio: 2/18) in a case-control study. All CM patients underwent a full and extensive clinical, neuropsychiatric, and neuropsychological evaluation to evaluate cognitive domains, including sustained attention (SA), information processing speed (IPS), visuospatial episodic memory, working memory (WM), and verbal fluency (VF), as well as depressive and anxiety symptoms. CM patients exhibited higher scores than HCs for all clinical and neuropsychiatric measures, but no differences were found in personality characteristics. Although more than half of the CM patients (54%) showed mild-to-severe neuropsychological impairment (NI), with the most frequent impairments occurring in short- and long-term verbal episodic memory and inhibitory control (in approximately 90% of these patients), almost half of the patients (46%) showed no NI. Moreover, the severity of NI was positively associated with the number of pharmacological treatments received. Remarkably, disease-related symptom severity and headache-related disability explained global neuropsychological performance in CM patients. The presence of cognitive and neuropsychiatric dysfunction during the interictal phase occurred in more than half of CM patients, increasing migraine-related disability and possibly exerting a negative impact on health-related quality of life and treatment adherence.
PB MDPI
SN 2077-0383
YR 2023
FD 2023-01-09
LK http://hdl.handle.net/10498/30748
UL http://hdl.handle.net/10498/30748
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026