RT journal article
T1 Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach.
A1 Chulian García, Salvador
A1 Martínez Rubio, Álvaro
A1 Marciniak-Czochra, Anna
A1 Stiehl, Thomas
A1 Blázquez, Cristina
A1 Rodríguez Gutiérrez, Juan Francisco
A1 Ramírez Orellana
A1 Castillo Robleda, Ana
A1 Pérez-García, Víctor M.
A1 Rosa Durán, María
A2 Matemáticas
K1 Mathematical medicine
K1 Haematopoiesis
K1 Mathematical modelling
K1 Lymphopoiesi
AB Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions of this process are associated with diseases like leukaemia, which is especially incident in children. The characteristics of self-regulation of this process make them suitable for a mathematical study.In this paper we develop mathematical models of lymphopoiesis using currently available data. We do this by drawing inspiration from existing structured models of cell lineage development and integrating them with paediatric bone marrow data, with special focus on regulatory mechanisms. A formal analysis of the models is carried out, giving steady states and their stability conditions. We use this analysis to obtain biologically relevant regions of the parameter space and to understand the dynamical behaviour of B-cell renovation. Finally, we use numerical simulations to obtain further insight into the influence of proliferation and maturation rates on the reconstitution of the cells in the B line. We conclude that a model including feedback regulation of cell proliferation represents a biologically plausible depiction for B-cell reconstitution in bone marrow. Research into haematological disorders could benefit from a precise dynamical description of B lymphopoiesis.
SN 0022-5193
YR 2021
FD 2021
LK http://hdl.handle.net/10498/30919
UL http://hdl.handle.net/10498/30919
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026