RT journal article T1 The Role of Adiposity in the Association between Muscular Fitness and Cardiovascular Disease A1 Pérez Pérez, Alejandro A1 Segura Jiménez, Víctor A1 Fernández Santos, Jorge del Rosario A1 Esteban-Cornejo, Irene A1 Gómez-Martínez, Sonia A1 Veiga, Oscar A1 Ascensión, Marcos A1 Castro Piñero, José A2 Didáctica de la Educación FísicaPlástica y Musical K1 weight status K1 muscular strength K1 mediation analysis K1 children K1 cardiometabolic risk factors K1 adolescents AB Objectives To test the associations of muscular fitness and body mass index (BMI), individually and combined, with clustered cardiovascular disease risk factors in children and adolescents and to analyze the mediator role of BMI in the association between muscular fitness and clustered cardiovascular disease risk factors.Study design In total, 239 children (113 girls) and 270 adolescents (128 girls) participated in this cross- sectional study. Height and weight were assessed, and BMI was calculated. A cardiovascular disease risk factors index (CVDRF-I) was created from the combination of the following variables: waist circumference, systolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and glucose. Handgrip strength/weight and standing long jump tests were used to assess muscular fitness. A muscular fitness index was computed from the combina- tion of both tests.Results Muscular fitness index was associated with CVDRF-I in children of both sexes and adolescent boys; however, these associations disappeared after accounting for BMI. BMI was associated with CVDRF-I in both children and adolescents, even after adjusting for muscular fitness (all P < .001). In male and female children and in adolescent boys, the association between muscular fitness and CVDRF-I was mediated by BMI (all P < .001). Because there was no association between muscular fitness and CVDRF-I in adolescent girls, the mediation hypothesis was discarded. Conclusions BMI is an independent predictor of CVDRF-I in children and adolescents of both sexes. Con- versely, the effect of muscular fitness on CVDRF-I seems to be fully mediated by BMI levels in male and female children and in adolescent boys. PB Elsevier SN 1097-6833 YR 2018 FD 2018 LK http://hdl.handle.net/10498/30985 UL http://hdl.handle.net/10498/30985 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 21-sep-2026