RT journal article
T1 Acute/Subacute and Sub-Chronic Oral Toxicity of a Hidroxytyrosol-Rich Virgin Olive Oil Extract
A1 Rodríguez Lara, Avilene
A1 Mesa, María Dolores
A1 Aragón-Vela, Jerónimo
A1 Casuso, Rafael A.
A1 Casals Vázquez, Cristina
A1 Zúñiga, Jesús M.
A1 Huertas, Jesús R.
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 acute toxicity
K1 hydroxytyrosol
K1 safety
K1 subacute toxicity
K1 subchronic toxicity
K1 virgin olive oil
AB The objective of this study was to determine the acute (one single dose), subacute (14 days), and sub-chronic (90 days) toxicity of an aqueous virgin olive oil (VOO) extract rich in hydroxytyrosol in rats. For acute/subacute toxicity, rats were divided into three groups. The control group received distilled water (n = 9), another experimental group received a single dose of 300 mg/kg (n = 3), and a third group received one dose of 2000 mg/kg (n = 4) during 14 days. The sub-chronic study included 60rats distributed in three groups (n = 20: 10 males and 10 females) receiving daily different three doses of the VOO extract in the drinking water during 90 days: (1) 100 mg/kg, (2) 300 mg/kg, and (3) 1000 mg/kg. In parallel, a fourth additional group (n = 20: 10 males and 10 females) did not receive any extract (control group). Clinical signs, body weight, functional observations of sensory and motor reactivity, hematological and biochemical analyses, and macroscopic and microscopic histopathology were evaluated. No adverse effects were observed after the administration of the different doses of the hydroxytyrosol-rich VOO extract, which suggests that the enrichment of VOO in its phenolic compound is safe, and can be used as functional foods for the treatment of chronic degenerative diseases.
PB MDPI
SN 2072-6643
YR 2019
FD 2019
LK http://hdl.handle.net/10498/31042
UL http://hdl.handle.net/10498/31042
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026