RT journal article
T1 Salen-manganese complexes for controlling ROS damage: Neuroprotective effects, antioxidant activity and kinetic studies
A1 Rouco, Lara
A1 Liberato González, Andrea
A1 Fernández-Trujillo Rey, María Jesús
A1 Máñez Muñoz, María Ángeles
A1 García Basallote, Manuel
A1 Alvariño, Rebeca
A1 Alfonso, Amparo
A1 Botana, Luis M.
A1 Maneiro, Marcelino
A2 Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica
K1 Manganese, oxidative stress
K1 Neuroprotection, Shiff bass
AB A new manganese(III) complex [MnL1(DCA)(H2O)](H2O), 1, has been prepared using the chelating ligand N,N’-bis(2-hydroxy-3-methoxybenzylidene)-1,2-diaminopropane (H2L1), and characterized by different analytical and spectroscopic techniques. The tetragonally elongated octahedral geometry for the manganese coordination sphere was revealed by X-ray diffraction studies for 1. The antioxidant behavior of this complex and other manganese(III)-salen type complexes was tested through SOD and catalase probes, and through the study of their neuroprotective effects in SH-SY5Y neuroblastoma cells. In this human neuronal model, these model complexes were found to improve cell survival in an oxidative stress model. During studies aimed to getting a better understanding of the kinetics of the processes involved in this antioxidant behavior, an important effect on the solvent in the kinetics of reaction of the complexes with H2O2 was revealed that suggests a change in the mechanism of reaction of the complexes. The kinetic data in methanol and buffered aqueous solutions correlate well with the results of the test of catalase activity, thus showing that the rate determining step in the catalytic cycle corresponds to the initial reaction of the complexes with H2O2.
PB ELSEVIER
SN 0162-0134
YR 2020
FD 2020
LK http://hdl.handle.net/10498/31136
UL http://hdl.handle.net/10498/31136
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 11-nov-2026