RT journal article T1 Effectiveness of non-pharmaceutical interventions in nine fields of activity to decrease SARS-CoV-2 transmission (Spain, September 2020–May 2021) A1 Barbeito, Inés A1 Precioso Garcelán, Daniel A1 Sierra Fernández, José María A1 Vegas Azcárate, Susana A1 Fernández Balbuena, Sonia A1 Vitoriano, Begoña A1 Gómez-Ullate Oteiza, David A1 Cao, Ricardo A1 Monge, Susana A2 Ingeniería en AutomáticaElectrónica, Arquitectura y Redes de Computadores A2 Ingeniería Informática K1 COVID-19 K1 effectiveness K1 hierarchical models K1 logarithmic return K1 on-pharmaceutical interventions (NPI) K1 pandemic AB Background: We estimated the association between the level of restriction in nine different fields of activity and SARS-CoV-2 transmissibility in Spain, from 15 September 2020 to 9 May 2021. Methods: A stringency index (0–1) was created for each Spanish province (n = 50) daily. A hierarchical multiplicative model was fitted. The median of coefficients across provinces (95% bootstrap confidence intervals) quantified the effect of increasing one standard deviation in the stringency index over the logarithmic return of the weekly percentage variation of the 7-days SARS-CoV-2 cumulative incidence, lagged 12 days. Results: Overall, increasing restrictions reduced SARS-CoV-2 transmission by 22% (RR = 0.78; one-sided 95%CI: 0, 0.82) in 1 week, with highest effects for culture and leisure 14% (0.86; 0, 0.98), social distancing 13% (0.87; 0, 0.95), indoor restaurants 10% (0.90; 0, 0.95) and indoor sports 6% (0.94; 0, 0.98). In a reduced model with seven fields, culture and leisure no longer had a significant effect while ceremonies decreased transmission by 5% (0.95; 0, 0.96). Models R2 was around 70%. Conclusion: Increased restrictions decreased COVID-19 transmission. Limitations include remaining collinearity between fields, and somewhat artificial quantification of qualitative restrictions, so the exact attribution of the effect to specific areas must be done with caution. PB Frontiers Media SN 2296-2565 YR 2023 FD 2023-04-12 LK http://hdl.handle.net/10498/31182 UL http://hdl.handle.net/10498/31182 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 10-may-2026