RT journal article
T1 Conventional Hospitalization versus Sequential Outpatient Parenteral Antibiotic Therapy for Staphylococcus aureus Bacteremia: Post-Hoc Analysis of a Multicenter Observational Cohort
A1 Castillo Fernández, Nerea
A1 Martínez Pérez-Crespo, Pedro María
A1 Salamanca Rivera, Elena
A1 Herrera Hidalgo, Laura
A1 de Alarcón, Arístides
A1 Navarro Amuedo, María Dolores
A1 Marrodán Ciordia, Teresa
A1 Pérez Rodríguez, María Teresa
A1 Sevilla Blanco, Juan
A1 Jóver Saenz, Alfredo
A1 Fernández Suárez, Jonathan
A1 Armiñanzas Castillo, Carlos
A1 Reguera Iglesias, José María
A1 Natera Kindelán, Clara
A1 Boix Palop, Lucía
A1 León Jiménez, Eva
A1 Galán Sánchez, Fátima
A1 del Arco Jiménez, Alfonso
A1 Bahamonde Carrasco, Alberto
A1 Vinuesa García, David
A1 Smithson Amat, Alejandro
A1 Cuquet Pedragosa, Jordi
A1 Reche Molina, Isabel María
A1 Pérez Camacho, Inés
A1 Merino de Lucas, Esperanza
A1 Gutiérrez Gutiérrez, Belén
A1 Rodríguez Baño, Jesús
A1 López Cortés, Luis Eduardo
A2 BiomedicinaBiotecnología y Salud Pública
K1 bacteremia
K1 outpatient parenteral antimicrobial therapy
K1 Staphylococcus aureus
AB It is not known whether sequential outpatient parenteral antimicrobial (OPAT) is as safe and effective as conventional hospitalization in patients with S. aureus bacteremia (SAB). A post-hoc analysis of the comparative effectiveness of conventional hospitalization versus sequential OPAT was performed in two prospective Spanish cohorts of patients with S. aureus bacteremia. The PROBAC cohort is a national, multicenter, prospective observational cohort of patients diagnosed in 22 Spanish hospitals between October 2016 and March 2017. The DOMUS OPAT cohort is a prospective observational cohort including patients from two university hospitals in Seville, Spain from 2012 to 2021. Multivariate regression was performed, including a propensity score (PS) for receiving OPAT, stratified analysis according to PS quartiles, and matched pair analyses based on PS. Four hundred and thirteen patients were included in the analysis: 150 in sequential OPAT and 263 in the full hospitalization therapy group. In multivariate analysis, including PS and center effect as covariates, 60-day treatment failure was lower in the OPAT group than in the full hospitalization group (p < 0.001; OR 0.275, 95%CI 0.129–0.584). In the PS-based matched analyses, sequential treatment under OPAT was not associated with higher 60-day treatment failure (p = 0.253; adjusted OR 0.660; % CI 0.324–1.345). OPAT is a safe and effective alternative to conventional in-patient therapy for completion of treatment in well-selected patients with SAB, mainly those associated with a low-risk source and without end-stage kidney disease.
PB MDPI
SN 2079-6382
YR 2023
FD 2023-01-09
LK http://hdl.handle.net/10498/31202
UL http://hdl.handle.net/10498/31202
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026