RT journal article
T1 Longitudinal effects of FTO gene polymorphism on body composition, cardiorespiratory fitness, physical activity, inflammatory markers, and cardiovascular risk in children and adolescents. “The UP & DOWN study”
A1 Mier Mota, Julián
A1 Ponce González, Jesús Gustavo
A1 Perez Bey, Alejandro
A1 Cabanas Sánchez, Verónica
A1 Veiga Núñez, Oscar
A1 Santiago Dorrego, Catalina
A1 Gómez Gallego, Félix
A1 Castro Piñero, José
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 cardiovascular disease
K1 childhood obesity
K1 FTO
K1 genotype
AB The role of polymorphism rs9939609 of the FTO gene has been related with fat mass and cardiovascular risk in adults, but it remains unclear in children and adolescents. Hence, the main aim of this study was to determine the FTO polymorphism effects on body composition, cardiorespiratory fitness (CRF), physical activity (PA), inflammatory markers, and cardiovascular risk both in cross-sectional analysis and after two-years of follow-up in children and adolescents. A total of 2129 participants were included in this study. The rs9939609 polymorphism was genotyped. Body composition measurements, CRF, and moderate-to-vigorous PA (MVPA) were determined at baseline and after two-year of follow-up. Moreover, plasma leptin and adiponectin were also determined as inflammatory markers. Furthermore, an index of cardiovascular disease risk factors (CVDRF-I) was calculated. Codominant (TT vs. TA vs. AA) and dominant (AA+AT vs. TT) models were applied for statistical analysis. The results showed a main effect of the FTO genotype on body composition measures in both first and third year (p < 0.05), with lower adiposity in TT compared with AA or AA+AT group. These differences were maintained after accounting for pubertal maturity, sex, age, VO2max, and MVPA. Moreover, lower leptin level was observed in TT compared to AA+AT group in the third year. An interaction in Gene*Time*Sex was found in height and neck circumference in dominant model (p = 0.047; p = 0.020, respectively). No differences were found in CRF, MVPA nor CVDRF-I between groups. Hence, homozygous TT allele could be a protective factor against weight gain from early childhood.
PB Wiley
SN 0905-7188
YR 2023
FD 2023-08-30
LK http://hdl.handle.net/10498/31225
UL http://hdl.handle.net/10498/31225
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026