RT journal article
T1 Relationship of early brain growth pattern measured by ultrasound with neurological outcome at two years of age in very low birth weight infants
A1 Ruiz González, Estefanía
A1 Lubián López, Simón Pedro
A1 Jiménez Luque, Natalia
A1 Segado Arenas, Antonio
A1 Lubián Gutiérrez, Manuel
A1 Marín Almagro, Yolanda
A1 Zafra Rodríguez, Pamela
A1 Méndez Abad, Paula
A1 Benavente Fernández, Isabel
A2 Materno-Infantil y Radiología
A2 Psicología
K1 Brain growth
K1 Brain volume
K1 Neurodevelopment
K1 Preterm
K1 Ultrasonography
K1 Very low birth weight infants
AB The purpose of this study is to define the impact of early brain growth trajectory in very low birth weight infants (VLBWI) on neurological prognosis at 2 years, assessed using sequential ultrasound (US) scans. This is a prospective cohort study with consecutive inclusion of VLBWI ≤ 32 weeks gestational age and ≤ 1500 g at birth. Total brain volume (TBV) was assessed using sequential 3D-US from birth to discharge. Prognosis at 2 years (corrected age) was assessed using the Bayley Scales of Infant and Toddler Development Third Edition. TBV showed slower growth with postmenstrual age (PMA) in those VLBWI who had an adverse cognitive prognosis compared to those with good cognitive prognosis (mean difference in TBV between prognostic groups from 4.56 cm3 at 28 weeks to 42.58 cm3 at 43 weeks) as well as in those with adverse language prognosis (mean difference in TBV from 2.21 cm3 at 28 weeks to 26.98 cm3 at 43 weeks) although other variables showed more impact than TBV on language prognosis (gestational age at birth, brain injury at term, and socioeconomic status). No association was found between TBV and motor prognosis. Brain growth rate was also significantly higher in those VLBWI who presented good cognitive scores (18.78 + (0.33 × (PMA-33)) cm3/week) compared to those with adverse cognitive outcome (13.73 + (0.64 × (PMA-33)) cm3/week). Conclusion: Early altered brain growth is associated with poor cognitive prognosis at 2 years of age. Using sequential US monitoring, we can detect early brain growth deviation in patients who will have adverse cognitive outcomes. What is known: • The prediction of neurodevelopmental outcome of VLBWI is mostly based on the presence of brain injury in US and structural magnetic resonance imaging (MRI) at term. • Some studies have related brain volume measured on MRI at term with neurodevelopment outcome. What is new: • VLBWI with adverse cognitive prognosis at two years of age present smaller brain volumes detectable by sequential US during NICU admission. • Brain volume can be estimated from 2D and 3D US and has prognostic value in VLBWI.
PB Springer
SN 0340-6199
YR 2023
FD 2023-09-08
LK http://hdl.handle.net/10498/31376
UL http://hdl.handle.net/10498/31376
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026