RT journal article
T1 Endothelial progenitor cells as biomarkers of diabetes-related cardiovascular complications
A1 Benítez Camacho, Josefa
A1 Ballesteros, Antonio
A1 Beltrán Camacho, Lucía
A1 Rojas Torres, Marta
A1 Rosal Vela, Antonio
A1 Jiménez Palomares, Margarita
A1 Sánchez Gomar, Ismael
A1 Durán Ruiz, María del Carmen
A2 Anatomía PatológicaBiología Celular, Histología, Historia de la Ciencia, Medicina Legal y Forense y Toxicología
A2 BiomedicinaBiotecnología y Salud Pública
K1 Diabetes mellitus
K1 Diabetic vascular complications
K1 Endothelial progenitor cells
K1 Biomarkers
AB Diabetes mellitus (DM) constitutes a chronic metabolic disease characterized by elevated levels of blood glucose which can also lead to the so-called diabetic vascular complications (DVCs), responsible for most of the morbidity, hospitalizations and death registered in these patients. Currently, different approaches to prevent or reduce DM and its DVCs have focused on reducing blood sugar levels, cholesterol management or even changes in lifestyle habits. However, even the strictest glycaemic control strategies are not always sufficient to prevent the development of DVCs, which reflects the need to identify reliable biomarkers capable of predicting further vascular complications in diabetic patients. Endothelial progenitor cells (EPCs), widely known for their potential applications in cell therapy due to their regenerative properties, may be used as differential markers in DVCs, considering that the number and functionality of these cells are affected under the pathological environments related to DM. Besides, drugs commonly used with DM patients may influence the level or behaviour of EPCs as a pleiotropic effect that could finally be decisive in the prognosis of the disease. In the current review, we have analysed the relationship between diabetes and DVCs, focusing on the potential use of EPCs as biomarkers of diabetes progression towards the development of major vascular complications. Moreover, the effects of different drugs on the number and function of EPCs have been also addressed.
PB Springer
SN 1757-6512
YR 2023
FD 2023-11-10
LK http://hdl.handle.net/10498/31396
UL http://hdl.handle.net/10498/31396
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-nov-2026