RT journal article
T1 The polygenic basis of relapse after a first episode of schizophrenia
A1 Segura, A.G.
A1 Prohens, Llucia
A1 Gassó, P.
A1 Rodríguez, N.
A1 Garcia-Rizo, C.
A1 Moreno-Izco, Lucia
A1 Andreu-Bernabeu, A.
A1 Zorrilla, I.
A1 Mane, A.
A1 Rodriguez-Jimenez, R.
A1 Roldán, A.
A1 Sarró, S.
A1 Ibáñez, A.
A1 Usall, J.
A1 Sáiz, P.A.
A1 Cuesta, M.J.
A1 Parellada, M.
A1 González-Pinto, Ana
A1 Berrocoso Domínguez, Esther María
A1 Bernardo, M.
A1 Mas, S.
A1 Mezquida, G.
A1 Arbelo, N.
A1 De Matteis, M.
A1 Galvañ, J.
A1 Duque Guerra, A.
A1 Arias i Queralt, L.
A1 Perez-Bacigalupe, M.
A1 Gonzalez-Ortega, I
A1 Toll, A.
A1 Casanovas, F.
A1 Sanchez-Pastor, L.
A1 Valtueña, M.
A1 Pomarol-Clotet, Edit
A1 García-León, M.A.
A1 Butjosa, A.
A1 Rubio-Abadal, E.
A1 Ribeiro, M.
A1 López-Ilundain, J.M.
A1 Saiz-Ruiz, J.
A1 León-Quismondo, L.
A1 Rivero, O.
A1 Ruiz, P.
A1 Echevarría, R.S.
A1 García Portilla, María Paz
A2 Neurociencias
K1 Cognition
K1 Polygenic risk score
K1 Relapse
K1 Schizophrenia
AB Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11–0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse.
PB Elsevier B.V.
SN 1873-7862
YR 2023
FD 2023
LK http://hdl.handle.net/10498/31472
UL http://hdl.handle.net/10498/31472
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 10-may-2026