RT editorial
T1 Editorial: Methods in T cell biology: 2022
A1 Aguado Vidal, Enrique
A1 Call, M.E.
A2 BiomedicinaBiotecnología y Salud Pública
K1 binding prediction
K1 machine learning
K1 method
K1 T cell
K1 T cell epitope
K1 TCR (T cell receptor)
AB T cells are crucial players of immune responses by their ability to specifically recognizeforeign, potentially harmful, antigens. To perform such specific recognition, T cells expressat their plasma membrane an antigen receptor called the T cell receptor (TCR) (1–3). TheTCR expressed at the plasma membrane in the majority of T cells is composed by a TCR-aand TCR-b heterodimer, which is able to recognize a complex formed by an antigenicpeptide coupled to an MHC molecule (pMHC complex). After specific recognition by apMHC complex the TCR triggers multiple intracellular signals leading to proliferation,target cell killing, cytokine secretion, and differentiation into effector T cells. Although ourunderstanding of the molecular mechanisms governing activation of T cells hasdramatically grown in recent years, there is still much to learn
PB Frontiers Media SA
SN 1664-3224
YR 2023
FD 2023
LK http://hdl.handle.net/10498/31473
UL http://hdl.handle.net/10498/31473
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 22-sep-2026