RT journal article
T1 Influence of Gender on Plasma Leptin Levels, Fat Oxidation, and Insulin Sensitivity in Young Adults: The Mediating Role of Fitness and Fatness
A1 Montes de Oca García, Adrian
A1 Perez Bey, Alejandro
A1 Corral Pérez, Juan
A1 Marín Galindo, Alberto
A1 Calderón Domínguez, María
A1 Velázquez Díaz, Daniel
A1 Casals Vázquez, Cristina
A1 Ponce González, Jesús Gustavo
A2 BiomedicinaBiotecnología y Salud Pública
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 fatty acid oxidation
K1 obesity
K1 insulin resistance
K1 cardiometabolic risk
K1 physical fitness
K1 dimorphism
AB It is unknown how plasma leptin affects fat oxidation depending on sex in young adults. Therefore, the present cross-sectional study aimed to examine the associations of plasma leptin with resting fat oxidation (RFO), maximal fat oxidation during exercise (MFO), and insulin sensitivity, considering the different responses in men and women, and the mediating role of fatness and cardiorespiratory fitness (CRF). Sixty-five young adults (22.5 ± 4.3 years; body mass index = 25.2 ± 4.7 kg·m−2, 23 females) participated in this study. Fasting plasma glucose, insulin, and leptin were analyzed. Variables related to insulin resistance (HOMA1-IR, HOMA2-IR), secretion (HOMA-%β), and sensitivity (HOMA-%S, QUICKI) were computed. RFO and MFO were determined through indirect calorimetry. A peak oxygen uptake (VO2peak) test was performed until exhaustion after the MFO test. The MFO was relativized to body mass (MFO-BM) and the legs’ lean mass divided by the height squared (MFO-LI). In men, leptin was negatively associated with MFO-BM and positively with HOMA-%β (p ≤ 0.02 in both). In women, leptin was positively associated with RFO and QUICKI, and negatively with MFO-BM (p < 0.05 in all). The association between leptin and MFO was mediated by CRF (p < 0.05), but not by fat mass (p > 0.05). Plasma leptin is associated with fat oxidation and insulin secretion/sensitivity, with different responses within each sex. The association between leptin and fat oxidation is mediated by cardiorespiratory fitness.
SN 2072-6643
YR 2023
FD 2023-06-04
LK http://hdl.handle.net/10498/31643
UL http://hdl.handle.net/10498/31643
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 08-nov-2026