RT journal article T1 Differentiating the influence of sedentary behavior and physical activity on brain health in late adulthood A1 Collins, Audrey M. A1 Molina-Hidalgo, Cristina A1 Aghjayan, Sarah L. A1 Fanning, Jason A1 Erlenbach, Emily D. A1 Gothe, Neha P. A1 Velázquez Díaz, Daniel A1 Erickson, Kirk I. A2 Didáctica de la Educación FísicaPlástica y Musical K1 Sedentary behavior K1 Physical activity K1 Aging K1 Brain health AB Public health messaging calls for individuals to be more physically active and less sedentary, yet these lifestylebehaviors have been historically studied independently. Both physical activity (PA) and sedentary behavior (SB)are linked through time-use in a 24-hour day and are related to health outcomes, such as neurocognition. Whilethe benefits of PA on brain health in late adulthood have been well-documented, the influence of SB remains tobe understood. The purpose of this paper was to critically review the evolving work on SB and brain health in lateadulthood and emphasize key areas of consideration to inform potential research. Overall, the existing literaturestudying the impact of SB on the components and mechanisms of brain health are mixed and inconclusive,provided largely by cross-sectional and observational work employing a variety of measurement techniques of SBand brain health outcomes. Further, many studies did not conceptually or statistically account for the role of PAin the proposed relationships. Therefore, our understanding of the way in which SB may influence neurocognition in late adulthood is limited. Future efforts should include more prospective longitudinal and randomized clinical trials with intentional methodological approaches to better understand the relationshipsbetween SB and the brain in late adulthood, and how these potential links are differentiated from PA. PB Elsevier SN 1873-6815 YR 2023 FD 2023 LK http://hdl.handle.net/10498/31658 UL http://hdl.handle.net/10498/31658 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 12-nov-2026