RT journal article
T1 A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation
A1 Fernández Aguilar, Luis Miguel
A1 Vico Barranco, Inmaculada
A1 Martínez de Arbulo Echevarría, Miguel
A1 Aguado Vidal, Enrique
A2 BiomedicinaBiotecnología y Salud Pública
K1 CD3
K1 ITAMs
K1 LAT
K1 Lck
K1 signaling
K1 TCR
K1 ZAP70
AB Specific antigen recognition is one of the immune system’s features that allows it to mount intense yet controlled responses to an infinity of potential threats. T cells play a relevant role in the host defense and the clearance of pathogens by means of the specific recognition of peptide antigens presented by antigen-presenting cells (APCs), and, to do so, they are equipped with a clonally distributed antigen receptor called the T-cell receptor (TCR). Upon the specific engagement of the TCR, multiple intracellular signals are triggered, which lead to the activation, proliferation and differentiation of T lymphocytes into effector cells. In addition, this signaling cascade also operates during T-cell development, allowing for the generation of cells that can be helpful in the defense against threats, as well as preventing the generation of autoreactive cells. Early TCR signals include phosphorylation events in which the tyrosine kinases Lck and ZAP70 are involved. The sequential activation of these kinases leads to the phosphorylation of the transmembrane adaptor LAT, which constitutes a signaling hub for the generation of a signalosome, finally resulting in T-cell activation. These early signals play a relevant role in triggering the development, activation, proliferation and apoptosis of T cells, and the negative regulation of these signals is key to avoid aberrant processes that could generate inappropriate cellular responses and disease. In this review, we will examine and discuss the roles of the tyrosine kinases Lck and ZAP70 and the membrane adaptor LAT in these cellular processes. © 2023 by the authors.
PB Multidisciplinary Digital Publishing Institute (MDPI)
SN 2079-7737
YR 2023
FD 2023
LK http://hdl.handle.net/10498/31659
UL http://hdl.handle.net/10498/31659
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 21-sep-2026