RT journal article T1 Determination of Gingerols and Shogaols Content from Ginger (Zingiber officinale Rosc.) through Microwave-Assisted Extraction A1 Gonzalez-Gonzalez, Montserrat A1 Yerena-Prieto, Beatriz Juliana A1 Carrera Fernández, Ceferino Adrián A1 Vázquez Espinosa, Mercedes A1 Velasco González de Peredo, Ana A1 Garcia Alvarado, Miguel Angel A1 Palma Lovillo, Miguel A1 Rodríguez-Jimenes, Guadalupe del Carmen A1 Fernández Barbero, Gerardo A2 Química Analítica K1 Box–Behnken design K1 gingerols K1 microwave-assisted extraction K1 response surface methodology K1 shogaol K1 UHPLC-QToF-MS K1 Zingiber officinaleRosc AB Ginger (Zingiber officinale Rosc.) is a plant recognized for its pungent taste and aromatic qualities, primarily derived from its underground rhizome. Apart from its widespread culinary applications, ginger is valued for its potential health benefits attributed to the presence of gingerols and shogaols. For this reason, this work proposes the development of a microwave-assisted extraction (MAE) method for the extraction of gingerols and shogaols present in ginger rhizomes. The influence of the extraction temperature (50–100 °C), the solvent composition (50–100% ethanol in water), and the sample-to-solvent ratio (0.3–0.7 g sample: 20 mL) on the extraction of these bioactive compounds has been studied. To this end, a Box–Behnken experimental design (BBD) in combination with a response surface methodology (RSM) has been applied. The optimum conditions for the total extraction of gingerols and shogaols were: 87% ethanol in water, 100 °C, and 0.431 g of ginger sample in 20 mL solvent. The developed method required short extraction times (5 min) and demonstrated favorable levels of repeatability and intermediate precision (CV < 5%). Finally, the MAE method was successfully used for the extraction of gingerols and shogaols from a variety of ginger samples. © 2023 by the authors. PB Multidisciplinary Digital Publishing Institute (MDPI) SN 2073-4395 YR 2023 FD 2023 LK http://hdl.handle.net/10498/31695 UL http://hdl.handle.net/10498/31695 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 05-nov-2026