RT journal article T1 Feed supplementation with winery by-products improves the physiological status of juvenile Liza aurata during a short-term feeding trial and hypoxic challenge A1 Martínez Antequera, Francisca Purificación A1 Molina Roque, Luis A1 Heras Rodríguez, Veronica de las A1 Mancera Romero, Juan Miguel A1 Martos Sitcha, Juan Antonio A1 Moyano, F.J. A2 Biología K1 Aquafeeds K1 Winery by-products K1 Bioactive compounds K1 Capacity antioxidant K1 Polyphenols AB The search of bioactive compounds obtained from natural sources with beneficial effects in growth and health isan increasing trend in aquaculture. Wine by-products are an excellent source of such compounds, mostly phenolics, with demonstrated antioxidant and immunostimulant activities in vertebrates. The present study evaluated the effects of dietary inclusion (100 g/kg) of two wine by-products (grape pomace and lees) on growth,immune status and metabolism of juvenile golden gray mullet (Liza aurata), as well as the potential protectiveeffect of compounds present in the two by products against induced stress produced by moderate hypoxia. Results evidenced a significant positive effect of grape pomace on feed efficiency, as well as in different indicators ofmetabolic and immunological status of the fish. Also, a significant negative effect of wine lees on the functionaldiversity of intestinal microbiota was evidenced. Fish fed on diets containing any of the two by-products evidenced significantly lower levels of cortisol when challenged by hypoxia, this pointing to a protective effectmediated by their contents in phenolic compounds and suggesting an interesting and practical application forthese agricultural by-products. PB Elsevier SN 2352-5134 YR 2023 FD 2023 LK http://hdl.handle.net/10498/31743 UL http://hdl.handle.net/10498/31743 LA eng DS Repositorio Institucional de la Universidad de Cádiz RD 10-nov-2026