RT journal article
T1 Influence of 12-Week Concurrent Training on Exosome Cargo and Its Relationship with Cardiometabolic Health Parameters in Men with Obesity
A1 Estébanez, Brisamar
A1 Amaro-Gahete, Francisco
A1 Gil González, Cristina
A1 González-Gallego, Javier
A1 Cuevas, María J.
A1 Jiménez Pavón, David
A2 Didáctica de la Educación FísicaPlástica y Musical
K1 concurrent training
K1 cardiometabolic health parameters
K1 exosomes
K1 males
K1 obesity
AB Exosome release varies depending on the physiological state of the cell, so they could playa fundamental role in obesity, the biggest pandemic in today’s societies. The beneficial effects thatphysical activity has both on weight and cardiovascular parameters may be mediated by exosomesreleased in response to exercise. Thus, we aimed (I) to study the influence of a 12-week CT interventionon exosome cargo modifications in men with obesity and (II) to determine whether changes inexosomes after the intervention were related to changes in cardiometabolic health parameters inour cohorts. An experimental, controlled design was performed in twelve (nine with valid data)adult male obese patients (mean values: 41.6 years old, 97.6 kg and 32.4 kg/m2) who were randomlydivided into a control group (n = 4) and a training group (n = 5), which completed 36 sessions ofCT (concurrent training) for 12 weeks. Before and after the training period, cardiometabolic healthparameters were evaluated and blood samples to measure exosomes and proteins were drawn. Nochanges were observed in the levels of any exosomal markers and proteins; however, associationsof changes between CD81 and both fat mass and weight, Flot-1 and VO2max, HSP70 and both CRPand left ventricle diastolic diameter or CD14 and leptin were found (all p ≤ 0.05). Although thecurrent CT was not able to clearly modify the exosome cargo, a certain medium to large clinical effectwas manifested considering the nature of this study. Moreover, the associations found between thepromoted changes in cardiometabolic parameters and exosome-carried proteins could indicate arelationship to be considered for future treatments in patients with obesity.
PB MDPI
SN 2072-6643
YR 2023
FD 2023
LK http://hdl.handle.net/10498/31761
UL http://hdl.handle.net/10498/31761
LA eng
DS Repositorio Institucional de la Universidad de Cádiz
RD 12-nov-2026